Adult onset obesity

Duration: 12min 40sec Views: 1180 Submitted: 15.11.2019
Category: Small Tits
Mitochondrial gene expression is essential for energy production; however, an understanding of how it can influence physiology and metabolism is lacking. Several proteins from the pentatricopeptide repeat PPR family are essential for the regulation of mitochondrial gene expression, but the functions of the remaining members of this family are poorly understood. We created knockout mice to investigate the role of the PPR domain 1 PTCD1 protein and show that loss of PTCD1 is embryonic lethal, whereas haploinsufficient, heterozygous mice develop age-induced obesity. The molecular defects and metabolic consequences of mitochondrial protein haploinsufficiency in vivo have not been investigated previously. We show that PTCD1 haploinsufficiency results in increased RNA metabolism, in response to decreased protein synthesis and impaired RNA processing that affect the biogenesis of the respiratory chain, causing mild uncoupling and changes in mitochondrial morphology. We demonstrate that with age, these effects lead to adult-onset obesity that results in liver steatosis and cardiac hypertrophy in response to tissue-specific differential regulation of the mammalian target of rapamycin pathways.

Adult-onset obesity is triggered by impaired mitochondrial gene expression

Childhood versus adult onset obesity in a comprehensive, multidisciplinary weight reduction program

Orlowski Hospital in Warsaw, Warsaw, Poland. Patients who are slated for bariatric surgery vary in terms of their age at onset of obesity, duration of obesity, and their health complications. Therefore, we aimed to explore a relationship between the age at onset of obesity, metabolic parameters, and health problems in bariatric surgery candidates. A total of unrelated adults with obesity prior to bariatric surgery were included in this study. Clinical, biochemical, anthropometric assessments, and DXA-derived measures were taken. Patients with early onset of obesity had a higher total body fat mass, and higher body fat percentage, and a 1.

Childhood versus adult onset obesity in a comprehensive, multidisciplinary weight reduction program

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